Key Skills

Job Description

Micro to macro: integrating neurobiological data through multilayer network analysis. Are you curious? Continue reading! About The Project Are you ready to help transform how we understand and treat oncological and neurological diseases? We are seeking an ambitious postdoctoral researcher to join a groundbreaking project that aims to bridge the biological scales of disease, from molecules to brain networks to cognition. In neurodegenerative and oncological diseases, including Alzheimer’s disease (AD) and glioma, early cellular and molecular changes eventually lead to brain network disruptions and cognitive decline. However, connecting these dots across levels of biology remains one of the greatest challenges in modern neuroscience. Our project addresses this challenge head-on, using multilayer network theory: an exciting analytical framework that allows us to model, quantify, and understand interactions within and between different biological scales. About The Role You will work at the forefront of this innovation, developing integrated network models that combine proteomic data (molecular scale) with brain network imaging (systems scale). Your goal is to identify the critical molecular and network targets that drive cognitive decline and, ultimately, to uncover new strategies for personalized therapeutic intervention. We already have a strong foundation for this goal: a toolbox that is data-type agnostic, that integrates across different network levels. This project sits at the intersection of computational neuroscience, systems biology, and clinical research. You will have access to rich multimodal datasets and will collaborate closely with a multidisciplinary team of neuroscientists, neurologists, and data scientists. If you are passionate about systems neuroscience, precision medicine, and innovative computational methods, and want to make a real impact on the future of research in this space, we would love to hear from you. Profile You hold a PhD in artificial intelligence, mathematics, bioinformatics, or a closely related discipline; You have experience in developing and implementing computational methods; You have strong programming skills, preferably in Python; You can communicate complex ideas clearly to non-specialists; You have excellent written and verbal communication skills in English, are self-motivated, and can work effectively in a multidisciplinary environment. Our offer You will be employed by Amsterdam UMC Research BV. A 12-month contract, with the intention to extend it to two years. Inschaling in salarisschaal 10: € 3.724 tot € 5.867 bruto bij een fulltime dienstverband (afhankelijk van ervaring). Daarnaast ontvang je 8,3% eindejaarsuitkering. Bereken hier jouw netto salaris (https://eur04.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.vismaraet.nl%2Fbruto-netto-salaris-berekenen%2F&data=05%7C02%7Cm.backer%40amsterdamumc.nl%7C3208330c6c4445c9774508dc8a23f340%7C68dfab1a11bb4cc6beb528d756984fb6%7C0%7C0%7C638537134157488597%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=%2BmJfznAdSYriZVd3QKf3cKnix0bGCh05OSS9T20Cevo%3D&reserved=0). Holiday hours: 194.4 per year for full time and a possibility to save additional hours. 100% reimbursement for public transport travel costs. If you travel by foot, bicycle, or car, a mileage allowance of €0.21 per km applies (up to a maximum of 40 km one way by car). Do you prefer walking or cycling? Take advantage of our good bike scheme. Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension. Watch this video (https://youtu.be/QO6mgb9R-sI) with more information about joining Amsterdam UMC Research BV. About The Workplace You will join the Multiscale Network Neuroscience (http://www.multinetlab.com/) (MULTINET) lab, where we aim to improve outcomes for patients with glioma and other conditions by understanding and leveraging personalized multiscale network data. Our multidisciplinary team focuses on three main goals: (1) embracing the complexity of brain networks by studying different populations with diverse methods; (2) integrating data across scales, from cells to brain networks to behavior, to uncover how local brain changes cause large-scale network disruptions in disease; and (3) predicting and treating clinical outcomes across brain tumors and other neurological or psychiatric conditions, focusing on shared symptoms like cognitive and physical impairments. We combine computational modeling, brain stimulation (TMS), and cellular experiments to reveal disease mechanisms and drive new treatments. You are also part of the ADORE Biocomputational Focus group, which unites Amsterdam UMC biocomputational researchers who develop and apply computational methods relevant to onco- and neurological applications. Amsterdam UMC Research BV Amsterdam UMC Research BV supports non-profit scientific research. In doing so, we provide researchers with everything they need to excel. Our principal investigators (PIs) and project leaders offer support in the field of project management, finance and human resources. In medical scientific research projects, legal support is also provided. Watch the video to find out more. Let's meet During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely. The first round of interviews is scheduled for the first week of December. If you have any questions about this position, please feel free to contact prof. dr. Linda Douw, project lead, at [email protected]. A reference check, screening and hiring assessment may be part of the procedure. Read here (https://werkenbij.amsterdamumc.org/nl/algemeen/medewerkerscreening) whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct). Internal candidates will be given priority over external candidates in case of equal suitability. Acquisition in response to this vacancy will not be considered.

Core Responsibilities

Develop integrated multilayer network models combining proteomic data with brain network imaging to investigate how molecular and network changes contribute to cognitive decline. Identify potential molecular and network targets for personalized therapeutic strategies, collaborating with a multidisciplinary team using multimodal clinical and research datasets.

Requirements

A PhD in artificial intelligence, mathematics, bioinformatics, or a closely related discipline is required, along with experience developing and implementing computational methods and strong programming skills, preferably in Python. Candidates should communicate complex ideas clearly, have excellent English communication skills, be self-motivated, and work effectively in a multidisciplinary environment.

Benefits

• End-of-Year Bonus
• 194.4 Annual Holiday Hours
• Public Transport Cost Reimbursement
• Mileage Allowance
• Bicycle Scheme
• Pension Accrual