Key Skills

Job Description

Do you want to contribute to research aimed at improving our understanding of diffuse midline glioma (DMG), an aggressive pediatric brain tumor for which treatment options remain limited? We are seeking a motivated Research Technician to join the Hulleman group and contribute to research investigating how medications used to manage symptoms in patients may influence tumor biology and treatment response. The project Diffuse midline glioma (DMG) is an aggressive pediatric brain tumor for which no curative treatment is currently available. Within the Hulleman group, we conduct preclinical translational research aimed at developing and improving treatments for this disease. In this project, we investigate how medications commonly used to manage symptoms in patients may influence the biological behavior of DMG, an area for which the impact on tumor biology remains unknown. Using our state-of-the-art mouse models of DMG, we aim to gain insight into how supportive care medications affect tumor cells, the surrounding normal brain tissue, and tumor-associated immune cells. This research will help us better understand the potential impact of supportive care on the disease and its treatment. Your tasks Perform laboratory animal studies using state-of-the-art mouse models of DMG. Conduct laboratory experiments using the MACSima spatial proteomics platform. Perform conventional immunohistochemistry and/or immunofluorescence. Apply a range of other laboratory techniques to investigate the effects of supportive care medications on DMG biology. Your profile A relevant educational background in Life Sciences, Biomedical Sciences, or a related field. Essential: You hold an Article 13f diploma to perform laboratory animal studies. Previous experience with laboratory animal research is preferred. Experience with the MACSima spatial proteomics platform is an advantage. Experience with conventional immunohistochemistry and/or immunofluorescence is an advantage. A motivated and precise approach to laboratory research, with an interest in contributing to research in pediatric neuro-oncology. Our offer This position offers the opportunity to contribute to preclinical translational research in pediatric neuro-oncology, working with advanced research models and technologies. You will be part of the Hulleman group, investigating how supportive care medications may influence DMG biology and treatment response. You will initially be appointed for a period of 1 year with the possibility of extension. Your gross monthly salary will depend on experience and background, starting in scale 45. You will also receive 8.33% gross monthly salary holiday allowance and 8.33% end-of-year bonus. The Princess Máxima Center operates according to the collective labour agreement ‘cao algemene ziekenhuizen’. The Princess Máxima Center The Princess Máxima Center for pediatric oncology is an integrated hospital and research institute, which integrates healthcare, research and education on pediatric cancer, in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe. Sluitingsdatum: 22 november 2026

Core Responsibilities

Conduct animal studies using mouse models of diffuse midline glioma and laboratory experiments using the MACSima spatial proteomics platform. Perform immunohistochemistry, immunofluorescence, and other laboratory techniques to investigate how supportive care medications affect tumor biology and treatment response.

Requirements

A relevant educational background in Life Sciences, Biomedical Sciences, or a related field is required, along with an Article 13f diploma for laboratory animal studies. Previous animal research experience is preferred; experience with MACSima and immunohistochemistry or immunofluorescence is an advantage.

Benefits

• Holiday Allowance
• End-Of-Year Bonus