Key Skills

Job Description

As a postdoctoral researcher at the ALS Center Netherlands, you will help develop the molecular biomarker arm of PLUS-ALS. You will have access to extensive, well-characterized patient cohorts and biobanks in both Utrecht and Leuven. About The Position As a postdoctoral researcher, you will be responsible for designing and independently conducting scientific research focused on the discovery and validation of molecular biomarkers for amyotrophic lateral sclerosis (ALS). Your responsibilities will include: Identifying new biomarker candidates from various types of omics data, including Olink and NULISA. Developing robust and efficient validation workflows. Translating promising biomarkers into panels suitable for clinical use. Performing laboratory research using techniques such as ECL, ELISA, western blotting, and related quantitative analytical methods. Collaborating with researchers in Utrecht and Leuven and regularly discussing research progress and findings. Analyzing research data and writing up results with statistical support from experienced methodologists. The department You will join the Department of Neurology and Neurosurgery at UMC Utrecht. The department conducts internationally leading research into neuromuscular disorders, including ALS and spinal muscular atrophy (SMA). You will be part of the ALS Center Netherlands and work on PLUS-ALS, a collaboration between the ALS centers in Utrecht and Leuven. The project aims to accelerate the development of ALS treatments through an innovative biomarker platform. You will have access to extensive, well-characterized patient cohorts and biobanks at both locations. You will work in an international team of researchers, clinicians, and methodologists. You will also collaborate with pharmaceutical partners through the TRICALS network. This collaboration allows you to combine scientific research with knowledge that can contribute to the development of new treatments for people living with ALS. Your profile You hold a PhD or are close to completing one in molecular biology, biochemistry, biomedical sciences, or a related field. You have demonstrable experience in proteomics, immunoassays, and/or biomarker validation. You are interested in translational research and applying research findings in clinical practice. Experience with amyotrophic lateral sclerosis (ALS) or other neurodegenerative disorders is an advantage. You can work independently and collaborate effectively within a multidisciplinary, international team. You have excellent written and spoken English skills. Our offer A salary between € 3.724 en € 5.867 gross per month (salary scale 10), based on full-time employment (36 hours). An employment contract for one year, with the possibility of an extension for the duration of PLUS-ALS (five years). Year-end bonus of 8.3% and holiday allowance of 8%. Pension insurance with ABP. We take care of approximately 70% of the monthly contribution. 100% public transport reimbursement. Are you coming on foot, by bike or by car? You will then receive a reimbursement of € 0.18 per km (by car up to a max. of 40 km one way). Possibilities to develop yourself personally and professionally. The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.

Core Responsibilities

Design and independently conduct research to discover and validate molecular biomarkers for ALS, using omics data and laboratory methods such as ECL, ELISA, and western blotting. Develop validation workflows and clinically suitable biomarker panels, analyze findings, and collaborate with researchers and methodologists in Utrecht and Leuven.

Requirements

Applicants must hold or be close to completing a PhD in molecular biology, biochemistry, biomedical sciences, or a related field, and have demonstrable experience in proteomics, immunoassays, and/or biomarker validation. The role also requires interest in translational research, independent and collaborative working abilities, and excellent written and spoken English; experience with ALS or other neurodegenerative disorders is an advantage.

Benefits

• Year-End Bonus
• Holiday Allowance
• Pension Insurance
• Public Transport Reimbursement
• Commuting Reimbursement
• Personal and Professional Development
• Additional Employment Benefits