PhD Multidimensional analysis of (a)biotic particles and immune responses
€3,217 - €4,077 per month
Key Skills
Job Description
We offer a PhD position to develop multidimensional flow-cytometry approaches, first using blood cells, then translating these to rapid characterization of inhaled particles such as microplastics and pollen and their immune effects. Dit ga je doen Small particles such as pollen and microplastics in the environment are involved in triggering inflammatory diseases, but current methods for monitoring these particles rely largely on labor-intensive identification approaches and provide limited information on the diversity of particles present. We aim to develop a novel portable system for rapid and multidimensional characterization of inhaled particles using portable flow cytometry. The candidate will develop the analytical and experimental approaches required to distinguish particles based on their multidimensional characteristics. As a first step, these approaches will be developed and validated using well-characterized blood cells, building on the group's expertise in flow cytometry and cellular heterogeneity. Subsequently, the technology will be adapted and translated to the characterization of particles in environmental samples. The project combines flow cytometry, multidimensional data analysis, cell and particle characterization, and technology development, ultimately aiming to bring laboratory-based measurements towards a portable system for real-world environmental monitoring. Hier ga je werken We are looking for a PhD student to join the PI group of Dr. Nienke Vrisekoop and develop a novel approach for multidimensional particle characterization, building on established expertise in flow cytometry and translating approaches from cellular to environmental particle analysis. The group of Dr. Vrisekoop is embedded within the Department of Respiratory Medicine as well as the Center for Translational Immunology. The group performs fundamental and translational research on immune cell dynamics in health and disease, with extensive expertise in multidimensional flow cytometry and advanced cellular analysis. This project will build on this expertise and extend it towards environmental particle characterization. This research project is part of the national NWA consortium project ExpACT. Dit neem je mee You (nearly) completed a MSc degree in a relevant area of research such as immunology, cellular biology, biophysics, analytical sciences, or a related discipline and have experience with laboratory research. Experience with flow cytometry, cell culture, microscopy, molecular biology or quantitative data analysis is a plus. You are interested in developing and applying novel technologies and are willing to learn and work across disciplinary boundaries. You collaborate with colleagues, share knowledge and skills, and contribute to a positive team environment. You plan and organize your work effectively and take responsibility for your own research. When experiments do not work as expected, you critically evaluate the results and explore alternative approaches. You communicate your findings clearly, both in writing and when presenting scientific data. You approach scientific questions with curiosity, take initiative and actively seek to understand and solve new problems. There is no fixed closing date for this vacancy. We will close the vacancy once we have found a suitable candidate. Dit bieden we jou Een salaris tussen de € 3.217 en € 4.077 bruto per maand (schaal OIO's), op basis van een fulltime dienstverband (36 uur). Eindejaarsuitkering van 8,3% en vakantietoeslag van 8%. Gunstige pensioenregeling bij ABP: wij betalen 70% van de premie. 100% vergoeding van je OV-kosten. Kom je lopend, fietsend of met de auto? Dan ontvang je € 0,21 per km (tot max. 40 km enkele reis). Mogelijkheden om jezelf persoonlijk en op werkgebied te blijven ontwikkelen. Cao à la carte: kies extra arbeidsvoorwaarden in ruil voor brutosalaris, zoals voor de aanschaf van een fiets, vergoeding van je internetabonnement en lidmaatschappen. Wij geloven in de kracht van een divers team waarin ruimte is voor verschillende vaardigheden, expertises, sociale en culturele achtergronden. Wij zijn benieuwd naar jou! Onze nieuwe collega's werven we zelf. We hebben geen behoefte aan acquisitie. Sollicitatieprocedure Is deze vacature iets voor jou? Solliciteer via de oranje button Dank voor je sollicitatie Je ontvangt meteen een ontvangstbevestiging van ons. Terugkoppeling Binnen twee weken na sluiting vacature hoor je van ons of je bent uitgenodigd. Selectieprocedure Samen kijken we of er een match is. Arbeidsvoorwaarden Bij een match volgt er een voorstel arbeidsvoorwaarden. Welkom! Wat fijn dat je bij ons aan de slag gaat! 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Core Responsibilities
The candidate will develop multidimensional flow-cytometry approaches to characterize inhaled particles and their immune effects. This involves translating laboratory-based measurements into a portable system for real-world environmental monitoring.
Requirements
Candidates must have a completed MSc degree in a relevant field such as immunology, cellular biology, or biophysics. Experience with laboratory research and flow cytometry is highly preferred.
Benefits
- End-of-year bonus of 8.3%
- Holiday allowance of 8%
- Pension scheme
- 100% public transport reimbursement
- Commuting allowance
- Professional development opportunities
- Flexible employment conditions (Cao à la carte)
- Internet subscription reimbursement
About UMC Utrecht
Industry: Hospitals and Health Care
Company size: 10,001+ employees
The University Medical Center Utrecht is one of the largest academic healthcare institutions in the Netherlands. We provide the best healthcare for today’s patients, and we also work towards a healthy society in the future. Our organization has three core tasks: care, research and education. Care for patients and employees Every day, we devote ourselves to providing adults and children with the best possible care, based on their specific needs and wishes. But we also care for our 11,000 employees. Because they have the knowledge, experience and expertise that we need in order to continue improving the care we provide. Our values Our mission is to continue to be a leading international institute. To achieve this, we ensure that: • We are involved and committed; • We constantly innovate and never stop learning; • We work together and take responsibility. Preserving the highest level of care Our scientific research is based on the world around us. Together with national and international partners, we invest in innovation and research in order to keep the care we provide at the highest level. Focus is essential, which is why we have selected six priority areas: • Brain • Infection & Immunity • Circulatory Health • Personalized Cancer Care • RM & Stem Cells • Child Health