Key Skills

Job Description

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about. Job Overview Are you ready for a new challenge? Responsibilities Join our in vitro Metabolism Team in Den Bosch and take on a role with a wide variety of tasks and responsibilities. At Charles River Laboratories Den Bosch we are currently hiring a: Experienced Analytical Chemistry Technician - in vitro Metabolism About Us At Charles River Laboratories, we help make the world a safer place by studying the behavior of substances before they reach the market. These substances include medicines, (agro)chemicals, and food ingredients, Our Discovery & Environmental Sciences department consists of about 90 talented professionals working on diverse projects for clients worldwide. Characteristic of the work is the great diversity of tests, test substances, customers and collaborations. About The Team Within the Discovery & Environmental Sciences department, you’ll join our in vitro metabolism section, a dynamic group that investigates how compounds are processed in the body and interact with biological processes. We test these compounds in various studies using in vitro models including hepatocytes, blood and plasma. The chemical analysis of these compounds is performed using mass spectrometry (LC-MS) to quantify them in biological materials. For some studies, we identify unknown metabolites using high-resolution LC-MS instruments, requiring complex scientific problem-solving. Our team consists of 9 study directors (scientific project managers) and 13 technicians. We work in an open, informal and flexible culture where collaboration and mutual support are key, and innovation is actively encouraged. About Your Role As an experienced technician, you’ll play a key role in performing a wide range of in vitro metabolism studies. You will perform various in vitro metabolism studies from sample pre-treatment, method development, implementation and sample analysis with LC-MS/MS. Next to the study work, you are involved in researching, developing and validating of new study setups. You will be working in a recently renovated laboratory (2021) equipped with new state-of-the-art analytical equipment. Your Profile A relevant applied science degree (HBO/HLO) in analytical chemistry or biochemistry Minimal 2 years’ experience with LC-MS/MS, including method development and validation Interest in identifying unknown compounds and using data analysis software (e.g., Xcalibur, Compound Discoverer, Empower and Masslynx) Strong communication skills in Dutch and English. A hands-on, creative problem-solving attitude. Proactive, results-driven, and flexible personality. Nice To Have Familiarity with biological test systems or biological materials Certification to work with radioactive materials Knowledge of Good Laboratory Practice (GLP) Job Description Our offer: Working at our organization means working in a dynamic international organization with a modern laboratory and a wide variety of equipment and techniques at your disposal. In addition, we offer excellent primary and secondary working conditions including: Ongoing training and support; 29.5 holidays on a full-time basis; Possibility to purchase 10 additional holidays per year; Annual one-off 8% holiday pay of your gross annual salary; Annual one-off payment based on company results; Travel allowance at €0.23 cents per kilometer with a maximum of €250 net per month or an NS Business Card; Bicycle (lease) plan; Collective pension with a own contribution of 2.9%; Company fitness membership; The opportunity to play sports with colleagues on our own sports field; The possibility of a consultation with our in-house ergonomist; Free fresh fruit every day. Education Physical Requirements About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. At Charles River Laboratories, we recognize and recruit all talent. We are a company committed to fostering a sense of belonging and work daily in this direction. 236031

Core Responsibilities

Perform in vitro metabolism studies including sample pre-treatment, method development, and analysis using LC-MS/MS. Research, develop, and validate new study setups within a state-of-the-art laboratory environment.

Requirements

Requires an applied science degree in analytical chemistry or biochemistry and at least 2 years of experience with LC-MS/MS. Candidates should be proficient in Dutch and English and possess a proactive, problem-solving attitude.

Benefits

• Ongoing training and support
• 29.5 holidays on a full-time basis
• Possibility to purchase 10 additional holidays per year
• Annual 8% holiday pay
• Annual performance-based payment
• Travel allowance
• Bicycle lease plan
• Collective pension
• Company fitness membership
• Access to company sports field
• In-house ergonomist consultation
• Free fresh fruit